It looks like I can add a layover in Frankfurt to my Italy trip. Can anyone suggest a clean budget hotel near the train station but not in the red light district. I will be there from a Friday to Monday. I have heard that some more expensive hotels have good weekend bargains as well. Some restaurant suggestions would also be appreciated.

Tim -
HERE is a link to the Venere website where you can get a listing of hotels in Frankfurt. At the end of the list, you can click to see more hotels - they just aren't bookable via Venere.

The Venere map shows you the location of the hotel in relation to the train station.